13:20 | September 11, 2022
Updated: 13:30 | September 11, 2022
This is what research data shows
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Data from the new study contradict previous findings of a cardiovascular benefit from taking the drugs in the evening.
Research presented at medical meetings is considered preliminary until published in a peer-reviewed journal. Predictions are that this will happen soon, as the data present results in a particularly large pool of patients.
Hypertension is diagnosed after multiple blood pressure measurements at several doctor visits. Diseased arterial pressure is suspected when, in two measurements in two outpatient visits, the average blood value exceeds 140/90 mmHg.
High blood pressure is the leading global cause of premature death. For example, it killed almost 10 million people in just one particular year. Of these, 4.9 million were due to ischemic heart disease and 3.5 million to stroke.
The statistics will be even more startling if the indirectly related fatal cases are added.
In our country, cardiovascular diseases are in first place in terms of frequency and as a cause of death. According to Eurostat, Bulgaria is one of the five countries in the European Union with the highest number of hypertensives.
Nocturnal rise in blood pressure is a better predictor of cardiovascular risks than daytime rise in blood pressure. This belief is supported by the idea that antihypertensive drugs taken in the evening, rather than in the morning, reduce blood pressure to a greater extent in the riskier period – at night.
The earlier study with the same focus – Hygia 2, showed a protective effect against cardiovascular events with an “evening” pill, but it provoked a lot of criticism, the announcement reminds.
The new TIME project is a prospective randomized trial – generally speaking, it meets high scientific criteria. It is one of the largest cardiovascular studies ever conducted. And according to the team behind it, it gives a definite answer to the question of whether blood pressure-lowering drugs should be taken in the morning or in the evening. The answer comes from comparing the health status of UK volunteers involved in the project.
They were randomly divided into two groups – 10,503 took their medication in the evening and another 10,601 in the morning. The average duration of follow-up was 5.2 years, but some participated in the study for more than nine years.
The study clearly found that heart attacks and strokes were almost equal regardless of the timing of the drugs, said lead researcher Prof Thomas Macdonald of the University of Dundee in Scotland.
The comparison showed that 3.4% of those who took their medication in the evening and 3.7% of those who took it in the morning were hospitalized for a heart attack, stroke or died of heart failure, it said 24 hours.